WorkPlan.

The project consists of seven work packages, as depicted below figure.

WP1 defines the clinical requirements and clinical user scenarios which serve as customer requirements for the technical solutions to be provided by the other WPs. As the main output, WP1 delivers functional requirements to be used in WP2. This WP builds a system architecture for the new medical image analysis and decision support sub-systems. WP2 forms the basis for the integration and validation of the developments of WP3 to WP5, towards their demonstration in WP6. WP3 develops three types of atlas models for organs and tissues, for cancer, neurodegenerative and cardiovascular diseases. These models serve as input for developing computer-aided detection and diagnosis techniques in WP4. Computational efficiency as well as robustness against anatomical, pathological and acquisition protocol variations will be of primary concern in WP4. These methods will be provided to WP5 Computerized Decision Support Systems, to provide a sound basis for image-based decision support.

Finally, WP6 collects the prototypes of WP 3 to 5 and combines these into several integrated demonstrators that are technically validated in a preferably business or end-user environment. This will be the basis for the exploitation of the Care4Me results. WP 3 to 5 are organized along three clinical applications / disease areas: cancer, neurodegenerative and cardiovascular diseases, represented in individual tasks in each WP. The matrix below shows the technological and clinical synergy that exists between the WPs and the clinical applications / disease areas. For each disease area, a WP will generate a dedicated clinical solution based on the technology developed in this WP.

Milestones.

M1 (m10): WP1 delivers the clinical requirements, clinical user scenarios and functional requirements. At the same time, WP3-5 deliver initial specifications. These documents need to be approved by the PMT, and set the stage for the design of the sub-systems in WP 2-5.

M2 (m16): WP2 specifies the initial system architecture and WP3 finalizes the design of and realizes the first model demonstrators. WP6 defines the planning for the integrated demonstrators.

M3 (m22): Major project milestone. WP1 defines the clinical process flows and refines the functional requirements. WP6 presents the design of the integrated demonstrators. WPs 4 and 5 finalize the design of and realize the first versions of the CAD and DSS demonstrators; these serve as input for the realization of the integrated demonstrators in WP6.

M4 (m28): WP2 refines the system architecture specifications while WP3 finalizes the second model demonstrators. Again, these serve as input for the realization of the integrated demonstrators in WP6.

M5 (m34): Major project milestone. WPs 4 and 5 finalize the second versions of the CAD and DSS demonstrators. The integrated demonstrators are realized and verified in WP6

M6 (m40): Final project milestone: the integrated demonstrators are validated in an end-user environment (e.g. hospital) against the requirements set in WP1. The validation proves the Care4Me concept and is used during dissemination. As a fall back scenario, the individual model, CAD and DSS demonstrators are tested and verified in WP3-5. The project is evaluated.

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